Advances in the Preclinical Study of Ischemic Stroke by M. Balestrino

By M. Balestrino

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2009). Green tea polyphenols down-regulate caveolin-1 expression via ERK1/2 and p38MAPK in endothelial cells. J Nutr Biochem 20 (12): 1021-1027. Y. L. (2003). Inhibition of vascular endothelial growth factor-induced angiogenesis by resveratrol through interruption of Src-dependent vascular endothelial cadherin tyrosine phosphorylation. Mol Pharmacol 64 (5): 1029-1036. W. & Chen. M. (2010). Resveratrol protects against oxidized LDL-induced breakage of the blood-brain barrier by lessening disruption of tight junctions and apoptotic insults to mouse cerebrovascular endothelial cells.

4. BrainsightTM hardware a) The peripheral hardware of BrainsightTM system comprises a computer and an optical position sensor (Polaris®); b) Additionally, a drill guide (not shown) and a ruler guide are available on request; c) The surgical instruments and hardware 30 Advances in the Preclinical Study of Ischemic Stroke operating table. On smaller tables, fix the animal with adhesive tape in the shoulder and hip region. The head rests on a foam rubber pad to ensure a stable and correct position.

1a/b, 2) that hold the fiducial markers (Fig. 1a/b, 4). The mouthpiece is inserted carefully, avoiding damage to or constriction of the tracheal tube. It can be adapted to the individual shapes of the maxillary molars and the hard palate by using thermoplastic, which cures within a few minutes. The fiducial markers are usually placed in the area between the cheeks and the ears. The maxillary splint has to be adapted to each individual sheep to ensure maximum precision. The splint has to be inserted for imaging and surgery.

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Advances in the Preclinical Study of Ischemic Stroke by M. Balestrino
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